Endocrine Abstracts

Introduction: Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking.Aim: Our aim was to study whether hyponatremia is associated with fractures, falls and/or bone mineral density (BMD).Methods: Five thousand two hundred and eight elderly men and women with serum sodium assessed at baseline were included from the prospective, population-based Rotterdam Study. The following da...

Background and aim: Parathyroid hormone (PTH) measurement is critical to evaluate bone status in patients with chronic renal failure as adynamic bone (AB) and bone with a high turnover (HTB) require different therapeutic options. Since the 2nd generation PTH assays recognise a non 1–84 PTH fragment in addition to the intact 1–84 PTH, a new assay defined as 3rd generation has been commercialised. The aim of this study was to evaluate, in dialysed patients, the rate of...

A 13-year-old girl with a history of developmental dyspraxia, enamel hypoplasia and a raised creatinine kinase (CK) presented to her GP with fatigue on any physical exertion including walking. On questioning she has always complained of muscle pain and tiring easily since she was a young child. On blood testing it was identified that she was profoundly hypocalcaemic with a calcium adjusted for albumin of 1.52 mmol/l, phosphate of 3.20 mmol/l, parathyroid hormone (PTH) of 1.5 p...

Introduction: Moderate hyperprolactinaemia occurring in a patient with a normal pituitary MRI, assuming macroprolactin and stress are excluded, is generally considered to be due to a lesion below the level of detection of the MRI scanner. Most patients with mild-moderate hyperprolactinaemia and a normal MRI respond to dopamine agonist therapy. We describe a patient who had prolactin elevation typical of a prolactin-secreting macroadenoma, but with a normal MRI, and in whom the...

Background: Lack of expression of MGMT (O-6-methylguanine-DNA methyltransferase) is associated with a better tumour response to temozolomide. There are no systematic studies of MGMT expression in pituitary tumour series.Aim: We introduced MGMT immunohistochemistry for all pituitary adenoma specimens in 2011. In this study we investigated the immunohistochemical expression of MGMT in a large series of pituitary adenomas, in order to determine (1) the over...

Background: In-patients inadequate food intake can worsen the prevalence and degree of malnutrition.Patients and methods: A “one day” questionnaire was used in medicine (M-Dpts) geriatric (G-Dpts) and surgery (S-Dpts) departments of a university hospital to: i) evaluate nutritional status with the Detky score, ii) quantify food intake, iii) understand the reasons of non-consumption of in-patients (n 286, 46 & 104 in M-, G- & S-Dpts, res...

Background: It is generally accepted that a post-operative cortisol of <50 nmol/l is a good predictor of long-term remission following trans-sphenoidal surgery (TSS).Aim: We wished to determine the rate of late recurrence and need for consequent intervention in patients who had initial biochemical remission after TSS for pituitary dependent Cushing’s.Methods: We performed a retrospective analysis of our patients who underw...

Background: Untreated Cushing’s disease has a high mortality rate. Transsphenoidal surgery is usually first line treatment and in the hands of a skilled experienced surgeon can achieve a cure rate of up to 80%. For those with recurrent or un-resectable disease, a combination of external beam radiotherapy, stereotactic radiotherapy, repeat transsphenoidal surgery, bilateral adrenalectomy and chemotherapy may be used. We investigated the safety and efficacy of stereotactic ...

Introduction: GLP-1 receptors have been fund on different types of neoplasm’ cells and density of these receptors appears to be more frequent in some of them. GLP-1 receptor scanning offers a new approach for successful localization of small or not detectable by other methods insulinomas and other cancers such as MTC, gastrinoma, pheochromocytoma, gastrinoma, etc.Aim of the study: The aim of study was to present first successful experiences with the...

Phaeochromocytomas (PCC) and paraganglioma (PGL) are neural crest tumours arising from the chromaffin producing cells of the adrenal medulla or sympathetic/parasympathetic system respectively. Recently, in part due to advances in high throughput sequencing, our understanding of the genetic predisposition to these tumours has greatly increased. To date, 13 genes have been implicated in the pathogenesis of these conditions (ten available for testing at our centre). Recent studie...